Proprietary vaccine development technologies
We are developing effective next-generation vaccines for the prevention and treatment of various infectious diseases and cancers based on unique original technologies such as our high-efficiency viral vector vaccine platform, built-in immunity enhancement technology, PREFER (Protein REFolding EnhanceR) technology, AI-based antigen remodeling technology, T cell immunity promotion technology, and cell/virus culture/purification technology.
We are also strengthening our development portfolio not only through our own capabilities, but also through active C&D (Connect & Development) with domestic and overseas innovative companies, and through continuous cooperation and joint research with innovative companies, we are searching, deriving, evaluating, and pursuing clinical/non-clinical development of new candidate substances.
1) Chimeric Adenovirus Vector Platform (Chim-Ad)
The chimeric adenovirus vector platform (Chim-Ad) fusers human adenovirus serotype 5 (Ad5) and adenovirus serotype (Rare type) rarely found in humans. It is a proprietary adenovirus vector source technology that improves the problem of pre-existing immunity in the existing Ad5 vector-based platform and improves vaccine productivity and immune induction capability. We are developing effective vaccine candidates based on Chim-Ad, and we are using the platform to develop premium vaccines against various new infectious diseases.
High immunogenicity
High level of cellular immune response
Heterologous prime-boost effect
Vaccine cost efficiency
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2) Built-in immunity enhancement technology
An adjuvant is used to induce quick and powerful immune response to vaccine antigens and to prolong the duration of immunity. Aluminum salts currently used in most vaccines have are excellent for inducing humoral immunity to form antibodies against antigens, but are disadvantageous for not inducing a cellular immune response. Therefore, various adjuvants are being developed to overcome this limitation.
We are utilizing genetic adjuvant technology that fuses ligands, which activate the immune system by binding to the toll-like receptors (TLR) of antigen presenting cells, with the vaccine antigens at the gene level to develop high-efficiency vaccines.
TLR | Ligand |
---|---|
TLR 1 | Tripalmitoyl-cysteine lipopeptides |
TLR 2 | Lipopeptides, beta-glucan, glycolipids |
TLR 3 | Double-stranded RNA |
TLR 4 | Lipopolysaccharide |
TLR 5 | Flagellin |
TLR 6 | Dipalmitoyl-cysteine lipopeptides |
TLR 7 | Single-stranded RNA |
TLR 8 | Single-stranded RNA |
TLR 9 | Bacterial DNA |
3) Protein REFolding EnhanceR Technology (PREFER)
If the recombinant protein produced in E. coli or yeast is converted into an insoluble inclusion body, it loses its biological activity and medical utility. Protein REFolding EnhanceR (PREFER), our protein activity restoration technology, is a technology that effectively restores the original medical activity by increasing the water solubility of recombinant proteins produced as insoluble inclusion bodies. This enables both mass production and effectiveness of medical protein materials at the same time.
We use our original PREFER technology, one of our core manufacturing technologies, for mass production of recombinant proteins in order to explore the efficacy of vaccine candidates and to mass-produce such candidates.
Securing Biological Effectiveness
Mass Production
Cost Reduction
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Solubilization
PREFER
(Protein
REFolding
EnhanceR)
4) AI-based Antigen Remodeling Technology
AI technology is aiding researchers and medical staff in the search for vaccine candidates, and designing and conducting clinical trials based on a vast library of immunity-related data. In particular, in addition to immuno-informatics software, AI-based modeling technology contributes to the selection of the best vaccine candidates by analyzing the three-dimensional structure of proteins faster and more efficiently and predicting the stability and efficacy of recombinant antigens. When viral or tumor-derived proteins with inherent risks are used as vaccine antigens, loss-of-function mutation should be induced for safety. At this time, due to the induced mutations, the distribution of antigenic peptides presented in linear and stereoscopic epitopes and major histocompatibility complexes (MHC) may differ from that of the wild-type antigens. Since this can lead to problems such as decreased immunogenicity and reduced stability of the vaccine antigen, optimization of the antigen sequence through physicochemical characterization of the protein is essential.
We design recombinant antigens based on immuno-informatics software and protein engineering technology and use AI-based antigen remodeling technology to perform structural analysis of vaccine candidates quickly and efficiently, and we conduct efficacy evaluation and clinical development for finally derived vaccine candidates.
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Efficacy and Saftey Test
Clinical Study